Our Science

  1. Chen, C-D, Podvin, S, Gillespie, E, Leeman, S and Abraham, CR. (2007) Insulin Stimulates the Cleavage and Release of the Extracellular Domain of Klotho via ADAM10 and ADAM17, PNAS. 104:19796-801. http://www.ncbi.nlm.nih.gov/pubmed/18056631
  2. Duce, JA, Podvin, S, Hollander, W, Kipling, D, Rosene, DL and Abraham, CR. (2008) Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. Glia. 56:106-17. http://www.ncbi.nlm.nih.gov/pubmed/17963266
  3. King, GD, Rosene, DL and Abraham, CR. (2012) Promoter methylation and age-related downregulation of klotho in rhesus monkey. Age, Sept. 16. 2011 Epub. 34:1405–1419. http://www.ncbi.nlm.nih.gov/pubmed/21922250
  4. King GD, Huang, MM, Schuman ER, Chen CD, Cuny GD, Glicksman MA, Abraham CR. (2012) Identification of novel small molecules to modulate transcription of Klotho. Biochem. J. 441:453-61. http://www.ncbi.nlm.nih.gov/pubmed/21939436
  5. Abraham, CR, Chen, CD, Cuny, GD, Glicksman, MA and Zeldich, E. (2012) Small Molecule Klotho Enhancers as Novel Treatment of Neurodegeneration. Future Medicinal Chemistry. 4:1671-9. http://www.ncbi.nlm.nih.gov/pubmed/22924505
  6. Chen, CD, Sloane, JA, Li, H, Aytan, N, Giannaris, EL, Zeldich, E, Hinman, JD, Dedeoglu, A, Rosene, DL, Bansal, R, Luebke, J, Makoto Kuro-o and Abraham, CR. (2013) The anti-aging protein Klotho enhances oligodendrocyte maturation and myelination of the central nervous system. J. Neurosci. January 30, 33:1927-39. http://www.ncbi.nlm.nih.gov/pubmed/23365232
  7. Tucker-Zhou, TB, King, GD, Chen, CD and Abraham, CR. (2013) Biochemical and Functional Characterization of the Klotho VS Polymorphism Implicated in Aging and Disease Risk. J. Biol. Chem. 288:36302–36311, December 20, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24217253
  8. Mehi, SJ, Maltare, A, Abraham, CR and King, GD. (2014) MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro. Age. Feb;36(1):141-9. Epub 2013 Jul 2. http://www.ncbi.nlm.nih.gov/pubmed/23818104
  9. Dubal, DB, Yokoyama, JS, Zhu, L, Broestl, L, Worden, K, Wang, D, Sturm, VE, Kim, D. Klein, E. Yu, G-Q, Ho, K, Eilertson, KE, Yu, L, Makoto Kuro-o, M, De Jager, PL, Coppola, G, Small, GW, Bennett, DA, Kramer, JH, Abraham, CR, Miller, BL, Mucke, L. (2014) Life extension factor klotho enhances cognition. Cell Reports. 7:1–12, May 22. http://www.ncbi.nlm.nih.gov/pubmed/24813892
  10. Chen, CD, Hu Li, H, Liang, J, Hixson, K, Zeldich, E, and Abraham, CR. (2014) The Anti-Aging and Tumor Suppressor Protein Klotho Enhances Differentiation of a Human Oligodendrocytic Hybrid Cell Line. J. Mol. Neurosci. 55:76-90. Jun 8. http://www.ncbi.nlm.nih.gov/pubmed/24907942
  11. Zeldich, E, Chen, CD, Colvin, TA, Bove-Fenderson, EA, Liang, J, Tucker Zhou TB, Harris, DA and Abraham, CR. (2014) The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J. Biol. Chem. Aug 29;289(35):24700-15. http://www.ncbi.nlm.nih.gov/pubmed/25037225
  12. Chen, C-D, Tung, T-Y, Liang, J, Zeldich, E, Turk, BE, and Abraham, CR. (2014) Identification of cleavage sites leading to the shed form of the anti-aging protein Klotho. Biochemistry. Sep 2;53(34):5579-87. http://www.ncbi.nlm.nih.gov/pubmed/25110992
  13. Dubal, D, Zhu, L, Sanchez, P, Worden, K, Broestl, L, Yu, G-Q, Kim, D, Kuro-o, M, Abraham, CR, Mucke, L. (2015) Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. J. Neurosci. 35(6):2358-2371. http://www.ncbi.nlm.nih.gov/pubmed/25673831
  14. Zeldich, E, Chen,CD, Avila, R, Medicetty, S and Abraham, CR. The anti-aging protein Klotho enhances remyelination following cuprizone-induced demyelination. J. Mol. Neurosci http://link.springer.com/article/10.1007/s12031-015-0598-2
  15. Abraham CR, Mullen PC, Tucker-Zhou T, Chen CD, Zeldich E. Klotho Is a Neuroprotective and Cognition-Enhancing Protein. In Gerald Litwack, editor: Klotho, Vol 101, VH, UK: Academic Press, 2016, pp. 215-238. http://www.ncbi.nlm.nih.gov/pubmed/27125744
  16. Massó A, Sánchez A, Gimenez-Llort L, Lizcano JM, Cañete M, García B, Torres-Lista V, Puig M, Bosch A, Chillon M (2015). Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression. https://www.ncbi.nlm.nih.gov/pubmed/26599613
  17. Masso, A, Sanchez, A, Bosch, A, Gimenez-Llort, L, Chillon, M (2017), Secreted αKlotho isoform protects against age-dependent memory deficits, Molecular Psychiatry, doi:10.1038/mp.2017.21, https://www.nature.com/mp/journal/vaop/ncurrent/full/mp2017211a.htm